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Melbourne ME/CFS Collaboration

Precision research program to identify the unique biology of individuals and the unifying biological pathways of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS).

About the research hub

Established in 2020, the Melbourne ME/CFS Collaboration, directed by Christopher W. Armstrong, PhD, is a hub of research innovation and collaboration for ME/CFS and related conditions.

Dr. Armstrong’s interest in ME/CFS research was sparked by his interactions with patients and clinicians during his PhD in Biochemistry at The University of Melbourne, leading to a dedicated pursuit of understanding these complex diseases.

Chris Armstrong, PhD, headshot

His innovative use of metabolomics to detect biochemical changes in patients was pivotal, capturing Linda Tannenbaum’s attention at a conference and resulting in his collaboration with Open Medicine Foundation (OMF) as a Science Liaison and a Visiting Scholar at Stanford University under Ronald W. Davis. This collaboration laid the foundation for OMF Australia, established to continue supporting Chris’ groundbreaking research upon his return to Melbourne.

The Melbourne ME/CFS Collaboration aims to decipher the common biological pathways in ME/CFS, acknowledging patient diversity in disease manifestation. Initially focusing on metabolic studies, the collaboration now champions precision medicine to understand each patient’s unique biology. Dr. Armstrong’s strategy includes expanding research networks within Australia and across the world, guiding new scientists in the field and bridging different patient groups to enhance collective understanding.

Under Dr. Armstrong’s leadership, the Melbourne ME/CFS Collaboration continues to be at the forefront of cutting-edge research, striving to unlock the complexities of ME/CFS and pave the way for targeted interventions and improved patient outcomes.


Itaconate Trap Study

This project aims to look at metabolic traps in central carbon metabolism that lead to observed altered energy production pathways in ME/CFS.

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Single Day Longitudinal Study

This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala).

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Deep Proteome and Metabolome Profiling

Collaborate with OMF CRCs in Uppsala and Melbourne to establish a global perspective.

Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM) through:

Deep phenotyping of ME patients
Global proteomic plasma profiling of ME patients
Global metabolomics plasma profiling of ME patients

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Ocular Motor Study

Ocular Motor Study   Study AIM The aim of this project is to fully characterise eye movement changes in ME/CFS on two consecutive days, identifying

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Developing Rapid System for Outlier Analysis in ME/CFS

Establish an analytical workflow for outlier analysis in ME/CFS to identify disease or symptom exacerbators that may not be considered in the individual with ME/CFS (including gene mutations, elevated toxins) and then develop a software program to rapidly identify these potential anomalies.

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Scientific Team

To carry out these ambitious projects, Dr. Armstrong is establishing networks and collaborations extending to USA, UK, Sweden, and other Australian institutions. 

University of Melbourne, Australia

Paul Gooley, PhD

Natalie Thomas, PhD

Kathy Huang

Amber Jaa-Kwee

Elena Christopolous

Xiaoyun Wang, PhD

David Fineberg, MD

Neil McGregor, PhD

David Ascher, PhD

Elisha Josev, PhD

Sarah Knight, PhD

Adam Scheinberg, MD

Elena Schneider-Futschik, PhD

Kristin Brown, PhD

Stanford University, USA

Ronald Davis, PhD

Michael Snyder, PhD

Robert Phair, PhD

Laurel Crosby, PhD

Ryan Kellogg, PhD

Julie Wilhelmy

Jaime Seltzer

Amit Saha, PhD

Harvard-Affiliated Hospitals, USA

David Systrom, MD

Wenzhong Xiao, PhD

Uppsala University, Sweden

Jonas Bergquist, MD, PhD

University of Montreal, Canada

Alain Moreau, PhD

Open Medicine Foundation

Linda Tannenbaum

UC San Diego, USA

Robert Naviaux, MD, PhD

University of Alabama Birmingham, USA

Jarred Younger, PhD

University College London, UK

Jo Cambridge, PhD

Michal Tal, PhD

Beth Pollack

La Trobe University, Australia

Sarah Annesley, PhD

Paul Fisher, PhD

Daniel Missailidis, PhD

Australian National University, Australia

Brett Lidbury, PhD

Alice Richardson, PhD

Monash University, Australia

Joanne Fielding, PhD

Meaghan Clough, PhD

Macquarie University, Australia

Benjamin Heng, PhD

OMF Australia Funded
Critical Research

OMF Australia Limited is a Health Promotion Charity, established for the purpose of promoting and funding research into multi-system chronic complex diseases, and supports the Melbourne ME/CFS Collaboration.

Learn about Our Other OMF Funded Collaborative Research Centers

OMF Australia accepts donations of Cryptocurrencies

Make the most of your donation by donating your Bitcoin, Ethereum, and other cryptocurrencies directly to OMF Australia rather than selling and donating the after-tax proceeds.

  • Your tax deduction will be equal to the fair market value of the donated cryptocurrency (as determined by a qualified appraisal).
  • Donors should consult with a tax advisor for properly recording this donation on a personal tax return.

OMF Australia can accept cryptocurrency donations of any amount. 

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