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Blood Flow and Exercise in ME/CFS and Orthostatic Intolerance

The study aims to investigate the effects of supine vs upright exercise on cerebral blood flow, blood pressure, heart rate, and the presence of autoimmune antibodies in ME/CFS patients with orthostatic intolerance, compared to controls, to understand the underlying mechanisms and differences in symptom severity and post-exertional malaise.

  • Elena Christopoulos
  • Kegan Moneghetti, FRACP, PhD
  • Paul Gooley, PhD
  • Christopher Armstrong, PhD
  • We are using an ultrasound doppler on the carotid along with an NIRS device to measure cerebral blood flow in the study.
  • Recruitment is expected to start in 2024.
  • Submitting systematic review paper to field interest.
STUDY HYPOTHESIS AND DESCRIPTION

Orthostatic intolerance (OI) is when people feel symptoms like light-headedness, dizziness, blurred vision, and sometimes fainting, especially when they stand up. This is because of instability in blood flow and pressure. Since 2003, recognizing these symptoms has been a key part of diagnosing ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome), a condition where OI is quite common. In some cases, these symptoms in ME/CFS patients are due to reduced blood flow to the brain rather than changes in how blood circulates upon standing.

We hypothesise that people with ME/CFS and OI will be impacted more by upright exercise versus supine exercise. This will be observed by reduced blood flow to the brain and/or reduced blood pressure and/or increased heart rate during and after exercise. We suspect this could lead to more severe post-exertional malaise (PEM), which is a worsening of symptoms following physical activity.

Additionally, the study predicts that there will be observable differences in metabolic processes in ME/CFS and OI patients before and after exercise, particularly during PEM, and these differences will be more pronounced in patients with both conditions.

OBJECTIVES
  1. Large blood cells coursing through a veinDetermine if CBF is further reduced in patients with both ME/CFS and OI during exercise and its effect on OI and PEM symptoms.
  2. Observe any hemodynamic abnormalities post-exercise/during PEM in ME/CFS and OI patients.
  3. Determine metabolic, genomic, proteomic or transcriptomic differences between patients with ME/CFS and OI.
  4. Investigate the presence of autoantibodies against adrenoceptors and muscarinic acetylcholine receptors in ME/CFS and OI.

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OMF Australia accepts donations of Cryptocurrencies

Make the most of your donation by donating your Bitcoin, Ethereum, and other cryptocurrencies directly to OMF Australia rather than selling and donating the after-tax proceeds.

  • Your tax deduction will be equal to the fair market value of the donated cryptocurrency (as determined by a qualified appraisal).
  • Donors should consult with a tax advisor for properly recording this donation on a personal tax return.


OMF Australia can accept cryptocurrency donations of any amount. 

Donating cryptocurrency is a non-taxable event, meaning you do not owe capital gains tax on the appreciated amount and can deduct it on your taxes. This makes Bitcoin and other cryptocurrency donations one of the most tax-efficient ways to support your favorite cause. If you want to learn more about how donating crypto can lower your taxes, check out thegivingblock.com/faq.

Talk to a crypto-savvy tax professional or connect with The Giving Block to get connected with one.

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