Temporally Resolved Omics Tracking of ME/CFS
Temporally Resolved Omics Tracking of ME/CFS Study AIM This study seeks to understand the biological mechanisms driving the symptomatology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using metabolomic and lipidomic high-throughput analysis and high-frequency blood sampling over a 6.5 to 7.5 hour period conducted at two separate sites (Melbourne and Uppsala). LEAD INVESTIGATORS Martin Lewis, PhD […]
General Practitioner Recruitment
General Practitioner Recruitment ME/CFS andLong COVID Myalgic Encephalomyeltis / Chronic Fatigue Syndrome (ME/CFS) is a multisystem, chronic and complex disease (msCCD) that, pre-COVID, affected around 230,000 Australians[1]. In 2020, the direct medical cost was estimated at $5.295b, or $23,022 per case per year, and the aggregate community cost at $14.5b per year[2]. Recent studies indicate […]
BOSS-ME: Biological Outlier and
Subtyping Software for ME/CFS
This project will develop a software tool to rapidly look for metabolism anomalies in an individual which might be explained by their genes. It will also look for potentially damaging genes in individuals and it will attempt to group ME/CFS patients based on their genetic and metabolic profiles.
Itaconate Trap Study
This project aims to look at metabolic traps in central carbon metabolism that lead to observed altered energy production pathways in ME/CFS.
Metabolic Differentiation of ME/CFS Comorbidities IBS and Fibromyalgia
This study will investigate the metabolite signatures of ME/CFS patient stool, urine and blood samples and the impact that co-morbidities (IBS and Fibromyalgia) have on these signatures.
Deep Proteome and Metabolome Profiling
Collaborate with OMF CRCs in Uppsala and Melbourne to establish a global perspective.
Decode the molecular mechanisms underlying ME/CFS and contributing to specific symptoms with a particular emphasis of post-exertional malaise (PEM) through:
Deep phenotyping of ME patients
Global proteomic plasma profiling of ME patients
Global metabolomics plasma profiling of ME patients
Ocular Motor Study for ME/CFS
The aim of this project is to fully characterise eye movement changes in ME/CFS on two consecutive days, identifying an ocular motor signature that is unique to the disorder.
Cellular Nitrogen and Energy Metabolism in ME/CFS
This project aims to test the nitrogen hypothesis, which is that damaging, nitrogen-containing by-products of energy metabolism accumulate more readily in the cells of ME/CFS patients.
SPOT-ME: Serial Pediatric Omics Tracking in ME/CFS
This study seeks to understand pathological mechanisms of pediatric ME/CFS (13 to 18 years old), using case-control and longitudinal study design that meshes clinical measures and omics methods.
Characterizing B cells in ME/CFS
This study aims to broadly evaluate B cell subsets, metabolism, viability, receptors, and antibodies in people with ME/CFS.
