The study will meticulously analyse daily changes in metabolites from blood samples of individuals with ME/CFS over 25 days, to uncover the complex biological processes contributing to the condition and facilitate patient clustering by dynamic changes, thereby addressing the challenge of clinical and biological diversity within the ME/CFS population.
We’re investigating how disruptions in energy metabolism play a role in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). While past studies have found differences in certain substances in the blood of ME/CFS patients compared to healthy people, there’s no consistent marker found yet. This might be because ME/CFS patients are quite diverse in both their symptoms and biology.
To tackle this, our study uses a method called repeated-measures design. This helps reduce differences between individuals and makes our findings more reliable, especially for conditions like ME/CFS where there’s a lot of variability.
We’re collecting blood samples from ME/CFS patients every day for 25 days. By carefully analyzing these samples using this method, we hope to understand better how the body’s chemistry changes over time in ME/CFS. Our aim is to group patients based on these changing patterns rather than just their static traits, which could lead to better ways to understand and treat ME/CFS in the future.
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